There was a statistically significant association between genotypes and FS. Results and conclusions: A greater proportion of the study participants had GG genotype (58%) and only 8.3% of the women had the AA genotype. Chi-square tests and the Kendall Tau-ḇ correlation test were used for a possible association and correlation between the variables, establishing a 95% confidence interval and significance level of p <0.05. Genotypic analyzes were performed using the PCR-SSP method followed by 1% agarose gel electrophoresis. Demographics and peripheral blood samples were collected for DNA extraction. Materials and methods: Participants in this cross-sectional study were 60 women over 18 years of age, 29 of the fibromyalgia group and 31 of the control group. The aim of this study was to analyze the relationship between polymorphism of the COMT G/A rs4680 gene in women with and without fibromyalgia. However, other studies did not verify such association, evidencing that this investigation is necessary for a better understanding. The single nucleotide polymorphism (SNP) in this gene most studied is rs4680 G / A, and individuals carrying the allele A have a greater sensitivity to pain. The catechol-O-metiltransferase (COMT) enzyme acts inactivating the catecholamines and mutations in the gene encoding this protein have been related to the symptoms of fibromyalgia. Regarding its physiopathology, studies have been associating the syndrome with a genetic predisposition related to the serotoninergic, dopaminergic and catecholaminergic systems. Luana Oliveira de Lima, Carlos Alexandre Martins Zicarelli, Andressa Saori Matsumura, Karen Barros Parron Fernandes, Layse Rafaela Moroti, Regina Célia Poli-Frederico UNIVERSIDADE NORTE DO PARANÁ, LONDRINA, PR, Brasilīackground: Fibromyalgia syndrome (FS) is characterized by chronic generalized musculoskeletal pain also associated with symptoms such as fatigue, sleep disorders and psychological. Recognition of this information is important in daily practice, as it may reflect in the difficulty of performing daily tasks, increasing level of sedentary lifestyle, besides being a prognosis of cardiovascular diseases. These findings corroborate with literature data that aerobic capacity is reduced in several systemic autoimmune diseases. In additional analysis, the reduced aerobic capacity was independent of type of SAM, disease duration, IMACS parameters and treatment.Ĭonclusions: Aerobic capacity was significantly reduced in SAM when compared to control group. Median aerobic capacity was lower in patients with SAM, when compared to control group (18.0 vs. Patients had low disease activity according of IMACS parameters, using different immunosuppressive drugs and with daily prednisone < 10mg. Results: Mean age of the patients was 47.9 years, with mean disease duration of 7.6 years. Disease status was evaluated by International Myositis Assessment and Clinical Studies Group (IMACS) core set measures. Aerobic capacity was evaluated by means of the treadmill maximum (Centurion 200, Micromed, Brazil) cardiorespiratory test, demonstrated through VO2max (mL/kg.min). Materials and methods: This is a cross-sectional study, from 2017 to 2018, that compared 23 female patients with SAM (2017 EULAR/ACR classification criteria: 13 dermatomyositis, 4 polymyositis and also 6 antisynthetase syndrome) with 17 aged, gender and body mass index-matched healthy individuals. Thus, the aim of the present study was to analyze aerobic capacity in SAM. However, few studies have assessed in SAM. Reduced aerobic capacity has been documented in several autoimmune rheumatic diseases. Alexandre Moura dos Santos, Rafael Giovane Misse, Jean Marcos de Souza, Diego Sales de Oliveira, Fernanda Rodrigues Lima, Ana Lúcia de Sá Pinto, Samuel Katsuyuki Shinjo FACULDADE DE MEDICINA DA UNIVERSIDADE DE SÃO PAULO, SÃO PAULO, SÃO PAULO, Brasilīackground: Systemic autoimmune myopathies (SAM) are a heterogeneous group of diseases that cause chronic muscle inflammation and progressive muscle weakness.
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